. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Physiol Behav. 2010 Jan 25;100(3):250–254. doi: 10.1016/j.physbeh.2010.01.015

Table 3.

Long non-coding RNA and chromatin modification

Chromatin Modifying Complex	Long Non-coding RNA	Function	Refs
Polycomb chromatin remodeling complex	HOTAIR	recruits to the HoxD locus to silence gene expression	67
	Tsix/RepA	RepA recruits the Polycomb complex to the X chromosome to induce heterochromatin formation and repress gene expression; Tsix inhibits this interaction	68
	Kcnq1ot1	recruits the Polycomb complex and the G9a histone modifying complex to the Kcnq1 domain to silence gene expression	69
Ash1	TRE transcripts	possible recruitment to Ultrabithorax (Ubx), a Drosophila homeotic gene, or cis- acting repression of transcription	70,71
Histone methyltransferase MLL1	Hoxb5/6as, Evx1as	associate with MLL1 and trimethylated H3K4 histones, suggesting a role in epigenetic regulation	72