Locomotor activity following challenge with dopaminergic drugs: Quinpirole (Quin), a selective D2, 3, 4 agonist, or SKF82958 (SKF) a selective D 1,5 agonist. Quinpirole was administered at 0.08 or 0.5 mg/kg ip (Quin .08 or Quin .5) and SKF 82958 at 1 or 10 mg/kg ip (SKF 1 or SKF 10). Saline dosing is indicated as sal. Data for adult males and females that had been injected with vehicle (control), cocaine at 25 mg/kg/day (Coc-25) or cocaine at 50 mg/kg/day (Coc-50) during postnatal days 11–20. * indicates significantly different from the response to saline within the group. Mean + sem