Table 1. Summary of functional studies by exposure period.
2DG studies @ 60 days of age- no drug challenge
| Prenatal | Postnatal 1–10 | Postnatal 11–20 | ||||
|---|---|---|---|---|---|---|
| ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | |
| Cortex | 0/7 | 2/7↓ | 1/7↑ | 1/7↓ | 5/7↑ | 1/7↑ 1/7↓ |
| Motor | 0/5 | 1/5↓ | 3/6↑ | 0/6 | 4/5↑ | 0/5 |
| Sensory | 0/7 | 1/7↓ | 3/6↑ | 0/6 | 1/8↑ | 1/8↑ |
| Limbic | 0/11 | 5/11↓ | 9/14↑ | 0/14 | 5/14↑ | 1/14↓ |
| Hypothal | 0/9 | 5/9↓ | 0/9 | 0/9 | 2/8↑ | 0/8 |
Brain metabolic activity using the 2-Deoxyglucose (2DG) method at 60 days of age with no drug challenge. Cocaine was administered during one of three developmental periods and results expressed as number of statistically significant differences/total number of regions analyzed within each functionally defined grouping (e.g., cortex, motor etc). The arrow indicates the direction of the change. Clearly males and females exhibit very different responses to cocaine when given during the three phases of brain development. [Hypothal = hypothalamic regions]