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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Autoimmun. 2009 Dec 24;34(4):453–459. doi: 10.1016/j.jaut.2009.11.017

Figure 6. γC399tr can inhibit cytokine production by activated T cells.

Figure 6

Splenocytes isolated from OTII Tg mice were in vitro cultured with either OVA peptide 5 μg/ml (6A-6C) or anti-CD3/anti-CD28 antibodies (6D) in the presence of increasing concentrations of γC399tr. 6A) Upper left- As the concentration of γC399tr is increased OVA-specific T cells secrete less IL-4 (circles). OTII cells incubated with control peptide did not secrete IL-4 (squares). 6B) Upper right- As the concentration of γC399tr is increased OVA-specific T cells secrete less IFNγ (circles). OTII cells incubated with control peptide did not secrete IFNγ (diamonds). 6C Bottom left- As the concentration of γC399tr is increased OVA-specific T cells secrete less IL-17 (circles). OTII cells incubated with control peptide did not secrete IL-17 (squares). 6D) Bottom right- γC399tr DID NOT inhibit IFNγ production by OTII T cells stimulated nonspecifically with anti-CD3 and anti-CD28 antibodies (circles). As the concentration of γC399tr is increased secretion of IFNγ is unchanged (triangles). OTII cells incubated with control peptide did not secrete IFNγ (squares).