Table 1.
Vaccine efficacy | Definition |
---|---|
VES | Vaccine efficacy of reducing susceptibility: the relative reduction in risk of acquisition due to vaccination is given by 1 − VES |
VEP | Vaccine efficacy of reducing shedding frequency: the relative reduction in the shedding frequency (given infection) due to prophylactic vaccination is given by 1 − VEP |
VEI | Vaccine efficacy of reducing infectivity during shedding episodes: the relative reduction in transmission probability per discordant partnership due to prophylactically vaccinating the index partner (given his/her infection and shedding) is given by 1 − VEI |
Stanberry, LR (2004) Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines. Herpes 11 Suppl 3: 161A–169A.
http://clinicaltrials.gov/ct2/show/NCT00057330 (2009) HerpeVac Trial for Young Women.