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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Gastroenterology. 2010 Jan 25;138(5):1920–1930. doi: 10.1053/j.gastro.2010.01.007

Figure 6. PD-0332991 treatment is highly effective in xenograft models irrespective of RB status.

Figure 6

(A) Huh7-miNS/miRB xenografts where treated with 150mg/kg PD-0332991. Nude mice where injected with BrdU 1 hour prior to sacrifice. Sectioned tumors were immunohistochemically stained and scored for BrdU. Relative BrdU incorporation from at least three independent experiments; bars, SD. Representative images of BrdU staining at 10x magnification. (B) Tumor samples were harvested and lysates were analyzed by immunoblot for the indicated proteins.