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NSS’s present within the amino acid sequence of PcrV
| Substitution | Total number of strains with NSS |
Frequency in each cohort |
||
|---|---|---|---|---|
| Japanese | US | French | ||
| L6F | 30 | 7 | 14 | 9 |
| A9G | 16 | 5 | 4 | 7 |
| A9S | 2 | 2 | 0 | 0 |
| A19D | 1 | 0 | 1 | 0 |
| S21P | 32 | 8 | 10 | 14 |
| E30K | 2 | 2 | 0 | 0 |
| Q83H | 1 | 1 | 0 | 0 |
| H107Y | 2 | 1 | 0 | 1 |
| Y192Sa | 2 | 0 | 0 | 2 |
| S196Na | 1 | 0 | 1 | 0 |
| L211Va | 1 | 0 | 1 | 0 |
| L224Fa | 1 | 1 | 0 | 0 |
| S225Ra | 31 | 10 | 13 | 8 |
| S225Ka | 9 | 0 | 5 | 4 |
| S225Ga | 2 | 0 | 2 | 0 |
NSS’s within the mAB166 epitope of PcrV
