Table 3.
Binding capacity, cytotoxicity and antagonicity of HCV NS3 peptides
| Sequence | Name | Peptide origin | Position | Peptide length (aa) | IC50 (nmol/L) | R2 | Cytotoxicity 10 nmol/L (%)1 | Inhibition1:1 (%) |
| CINGVCWTV | Wt1073 | HCV NS3 | 1073-1081 | 9 | 54 640 | 0.994 | 86.74 | - |
| CINGVSWTV | C1078S | HCV NS3 | wt1073 (C6S) | 9 | 1271 | 0.993 | 24.57 | 59.30 |
| YINGVCWTV | C1073Y | HCV NS3 | wt1073 (C1Y) | 9 | 1627 | 0.999 | 45.21 | 44.70 |
| CINGVCRTV | W1079R | HCV NS3 | wt1073 (W7R) | 9 | 297 500 | 0.991 | 21.02 | 54.50 |
| YLVTRHADV | Wt1131 | HCV NS3 | 1131-1139 | 9 | 4800 | 0.995 | 52.03 | - |
| YLVMRHADV | T1134M | HCV NS3 | wt1131 (T4M) | 9 | 7200 | 0.991 | 44.53 | 36.75 |
| YLVTRYADV | H1136Y | HCV NS3 | wt1131 (H6Y) | 9 | 7401 | 0.993 | 35.56 | 92.54 |
| CLVTRHADV | Y1131C | HCV NS3 | wt1131 (Y1C) | 9 | 8345 | 0.995 | 2.01 | 67.89 |
| YLVTRRADV | H1136R | HCV NS3 | wt1131 (H6R) | 9 | 27 700 | 0.993 | 14.53 | 47.46 |
| LLCPAGHAV | Wt1169 | HCV NS3 | 1169-1177 | 9 | 35 440 | 0.999 | 84.56 | - |
| LLCPAGHTV | A1176T | HCV NS3 | wt1169 (A8T) | 9 | 27 640 | 0.998 | 27.75 | 61.42 |
| LLRPAGHAV | C1171R | HCV NS3 | wt1169 (C3R) | 9 | 82 100 | 0.997 | 59.98 | 44.39 |
| FLPSDFFPSV | HBV-Core | HBV Core | (18-27)[99] | 10 | 481.1 | 0.999 | NS | NS |
| SLYNTVATL | HIV-p17 | HIV-1 p17 | (77-85)[100] | 9 | 4248 | 0.984 | NS | NS |
| ILKEPVHGV | HIV-RT | HIV-1 Pol | (476-484)[47] | 9 | 7082 | 0.997 | NS | NS |
1
Means of two experiments. Variant substitutions are expressed in underlined letters.