Fig. 3.

A model for Vps34 activation on membranes. (A) A close-up for the closed form of the enzyme in the cytosol. The C-terminal helix protects the phosphotransferase center from water. (B) The transition of the enzyme from a closed form in the cytosol (C-terminal helix in) to an open form with the C-terminal helix interacting with the membrane. The C2 domain (cyan) modelled as in Fig. 1. Vps15-interacting regions are classified as strong (red) or weak (orange) (27).