Figure 6.
The miRNA network in acute myeloid leukemia (589 samples, two subnetworks). Standard Banjo parameters were adopted with a q6 discretization policy. The consensus graph depicted here was obtained from the best 100 nets (after searching through 8.5 × 109 networks). The miRNA network in AML has disjointed cliques. hsa-miR-155 and hsa-miR-181, two miRNAs with clinical relevance are in two separated subnetworks, as expected from their prognostic independence. hsa-miR-181 is associated with hsa-miR-146a in a detached yellow miniclique. mir-155 belongs to the main subnetwork, in the same red MCL clique of hsa-miR-223, hsa-miR-92a, hsa-miR-25, and hsa-miR-32. Finally, hsa-miR-29b has a key role in AML and acts as a hub in the AML net.