Figure 7.

The miRNA network in chronic lymphocytic leukemia (254 samples, three subnetworks). Standard Banjo parameters were adopted with a q6 discretization policy. The consensus graph depicted here was obtained from the best 100 nets (after searching through >1 × 10¹⁰ networks). The network graph shows a major net and two separated minicliques: hsa-miR-23a/b and the hsa-miR-15/16 cluster. hsa-miR-15 and hsa-miR-16, two miRNAs frequently deleted in CLL, have been shown to regulate apoptosis via BCL2. The key hsa-miR-29b, acting as a hub in AML, is only a branch in CLL. AML prognostic hsa-miR-181 is disjointed in AML but not in CLL, while the reverse happens in CLL for prognostic hsa-miR-15/16 genes.