Figure 7.
Effects of lidocaine and flecainide on the recovery and development of inactivated-state block of the human cardiac Nav1.5 channels in CHO cells transfected with the corresponding cDNA. Upper part: recovery from inactivation: the data were fitted to a double exponential function for solvent (n= 6) and lidocaine (100 µM; n= 6), and by a triple exponential function for flecainide (10 µM; n= 6). In contrast to flecainide, lidocaine prolonged the recovery from inactivation. Lower part: development of inactivated-state block: the data were fitted to a single exponential function for solvent (n= 6), lidocaine (100 µM; n= 6) and flecainide (10 µM; n= 6). Lidocaine, in contrast to flecainide, developed an inactivated-state block. Data are mean ± SEM.