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Use-dependent effect and recovery of block by flecainide on the human cardiac Nav1.5 channels and the resulting INa. Upper part: use-dependent effect of flecainide (10 µM; n= 5). The data were fitted to a single exponential function. Lower part: recovery from use-dependent block. The data were fitted to a double exponential function for solvent (n= 5), and by a triple exponential function for flecainide (10 µM; n= 5). Data are mean ± SEM.
