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Different PKs exhibit different substrate preferences on Ser or Thr residue. From the Phospho.ELM 8.2 database (19), we collected 377, 347, 36, and 38 experimentally verified phosphorylation sites for four well studied PK groups, including AGC/PKA, CMGC/CDK, AGC/PDK1, and AGC/DMPK/ROCK, respectively. For AGC/PKA (A) and CMGC/CDK (B), the Ser is the preferred residue, whereas the Thr residue is more preferred for AGC/PDK1 (C) and AGC/DMPK/ROCK (D).
