Table I. List of proteins that were altered in cells overexpressing TDP-43 or TDP-S6.
The log2 ratios summed over all molecular mass regions (gel bands 1–5) are shown as the mean of two biological replicates ±S.E. If the proteins were quantified only in one experiment, the S.E. value was not available. NC, not changed (the measured difference was not statistically significant). The accession numbers are from the National Center for Biotechnology Information Reference Sequence Database.
| Accession no. | Protein names | log2(TDP-43/control) | log2(S6/control) | log2(S6/TDP-43) |
|---|---|---|---|---|
| Proteins affected by TDP-43 and TDP-S6 expression | ||||
| NP_031401.1 | TDP-43 or TDP-S6 | 2.8 ± 0.3 | 3.7 ± 0.3 | 1.3 ± 0.4 |
| NP_002945.1 | Ubiquitin | NC | 1 ± 0.4 | 1 ± 0.4 |
| NP_008868.3 | SUMO-2/3 | 0.9 | 2.4 ± 0.0 | 1.2 ± 0.3 |
| NP_005726.1 | ARP1 | 1.2 ± 0.5 | 2.8 | NC |
| Proteins affected by TDP-S6 expression | ||||
| NP_006169.2 | N-Ethylmaleimide-sensitive factor | NC | −1 | −1.2 ± 0.5 |
| NP_056384.2 | Dynamin 3 | NC | −2.5 | −1.2 ± 0.6 |