Table II. Assessment of serum Mac-2BP as marker for all gastroenteropancreatic (GEP) NETs and midgut NETs.
The detection rate (sensitivity) is the total true positive results divided by the true positive and false negative results. The false positive rate (FPR) is 100% − specificity. CI is the confidence interval. Likelihood ratio (LR) is sensitivity divided by 1 − specificity. At levels of >3.58 μg/ml, Mac-2BP is 100% specific for NETs.
| Detection rate (sensitivity) | CI | Mac-2BP in all GEP NETs |
Mac-2BP in midgut NETs |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cutoff | FPR | CI | LR | Cutoff | FPR | CI | LR | ||
| % | % | μg/ml | % | % | μg/ml | % | % | ||
| 47 | 32.1–61.9 | >3.58 | 0 | 85.6–100 | >3.59 | 0 | 85.6–100 | ||
| 75 | 59.7–86.0 | >2.41 | 41.7 | 22.2–63.4 | 1.80 | >2.91 | 29.2 | 12.2–44.6 | 2.56 |
| 80 | 66.7–90.9 | >2.06 | 58.3 | 37.4–78.2 | 1.37 | >2.30 | 50.0 | 29.2–61.8 | 1.60 |
| 85 | 71.7–93.8 | >1.97 | 58.3 | 36.4–77.2 | 1.46 | >2.02 | 58.3 | 36.4–77.9 | 1.46 |
| 90 | 76.9–96.5 | >1.72 | 66.6 | 45.3–84.3 | 1.35 | >1.94 | 58.2 | 37.0–77.7 | 1.55 |
| 95 | 85.5–99.5 | >1.65 | 70.2 | 45.3–84.3 | 1.35 | >1.70 | 66.6 | 44.7–84.3 | 1.43 |