Table 1.
Basal dialysate levels of DA, DOPAC and HVA from the striatum of animals injected in the right substantia nigra 3 weeks earlier with vehicle,NTN or GDNF
| Group | Dialysate level (nM) |
||
|---|---|---|---|
| DA | DOPAC | HVA | |
| Vehicle | |||
| Left striatum | 4.74 ± 0.44 | 1,731 ± 40 | 940 ± 33 |
| Right striatum | 5.11 ± 0.47 | 1,749 ± 102 | 1,006 ± 51 |
| NTN | |||
| Left striatum | 4.58 ± 0.38 | 1,850 ± 126 | 1,057 ± 58 |
| Right striatum | 4.71 ± 0.26 | 1,317 ± 154* | 847 ± 69* |
| GDNF | |||
| Left striatum | 5.10 ± 0.41 | 1,815 ± 65 | 1,044 ± 28 |
| Right striatum | 4.81 ± 0.30 | 1,437 ± 128* | 926 ± 47* |
Values are mean ± SEM from 7–8 animals per group
*
P < 0.05 versus left striatum (mixed ANOVA followed by New-man-Keuls post hoc comparisons)