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. Author manuscript; available in PMC: 2010 Apr 27.
Published in final edited form as: J Infect Dis. 2007 Aug 15;196(Suppl 1):S35–S45. doi: 10.1086/518657

Table 2.

Recommendations for when to initiate antiretroviral therapy for symptomatic HIV-infected patients.

Source of recommendation [reference] Date of
publication		 CD4 cell
count, cells/mm3 		Plasma HIV RNA
level, copies/mL
International AIDS Society–USA Panel [30] Jul 1998 Any >5000–10,000
International AIDS Society–USA Panel [31] Jan 2000 <500 >5000–30,000
Panel on Clinical Practices for Treatment of HIV [32] Feb 2001 <350 >30,000
Panel on Clinical Practices for Treatment of HIV [33] May 2002 <350 >55,000
International AIDS Society–USA Panel [34] July 2002 >200 >50,000–100,000
Panel for Clinical Practices for Treatment of HIV [35] Nov 2003 200–350 >55,000
WHO guidelines, 2003 revision [36] Dec 2003 ≤200 NA

NOTE. NA, not applicable; WHO, World Health Organization.