Table 1.
Baseline characteristics in 2,736 participants
| PPD-positive |
Anergy |
|||||
|---|---|---|---|---|---|---|
| Characteristics | Placebo (n = 464) |
6H (n = 536) |
3HR (n = 556) |
3HRZ (n = 462) |
Placebo (n = 323) |
6H (n = 395) |
| Male, % | 31 | 31 | 29 | 34 | 31 | 32 |
| Mean age, years | 30 | 29 | 29 | 29 | 30 | 30 |
| Body mass indexa | 22.2 | 22.1 | 22.6 | 22.3 | 22.9 | 21.9 |
| Karnofsky score | 91 | 91 | 91 | 91 | 90 | 90 |
| PPD skin test | 14 | 14 | 13 | 14 | 0 | 0 |
| Hemoglobin, g/L | 126 | 125 | 127 | 126 | 125 | 123 |
| Platelet count, /L | 264 | 258 | 264 | 262 | 267 | 264 |
| Creatinine, mg/dL | 0.89 | 0.88 | 0.89 | 0.9 | 0.94 | 0.84 |
| AST/SGOT, U/L | 27.1 | 27.7 | 26.3 | 26.4 | 28.1 | 27.9 |
| Absolute lymphocyte count per mm3 |
2245 | 2327 | 2309 | 2223 | 1968 | 2116 |
| Pruritic papules, % | 8 | 12 | 10 | 8 | 20 | 19 |
| Previous herpes zoster or thrush, % | 25 | 25 | 25 | 27 | 33 | 35 |
Note: PPD = purified protein derivative; 6H = isoniazid (INH) for 6 months; 3HR = INH plus rifampicin for 3 months; 3HRZ = INH plus rifampicin plus pyrazinamide for 3 months.
a
The body mass index was calculated as the weight in kilograms divided by the square of the height in meters.