Figure 6. Reactivation of latent herpes simplex virus.
Organs were harvested from mice >30 days after being given 108 rRp450 intravenous and explanted into cultures. Infectious virus production was detected in 7/8 trigeminal ganglia (TGs) harvested from four animals inoculated into the cornea with a wild-type virus (positive control), but not in organs from animals given systemic rRp450 and KOS (“all others” include TG, dorsal root ganglion, spleen, kidney, liver, adrenal).