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. 2010 Apr 1;3:5. doi: 10.1186/1755-1536-3-5

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Copyright ©2010 Veidal et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rat liver results. (a) Liver weight in bile duct ligated (BDL) or sham-operated rats. Data are shown as mean ± standard error of the mean (SEM). ***P < 0.0001. (b) Scoring of the structural changes in the livers of each group. Data are shown as mean ± SEM. (c) Masson's trichrome photomicrographs showing the hepatic structure in rats 5 weeks after a sham operation (c2), 2 weeks after BDL (c3), 4 weeks after BDL (c4) and 5 weeks after BDL (c5). The structure of the hepatic lobules around the portal tract (arrows) is clearly disrupted in the BDL rats compared with the sham-operated rats. (d) Immunohistochemical analysis of type I collagen. Type I collagen is localised around fibrotic structures. Original magnification × 40 or × 100.