Figure 1.

p38 MAPK mediates the transcriptional response to stress. The p38 MAPK pathway is activated by stresses and leads to the phosphorylation of a number of transcriptional regulators that can orchestrate a program of gene expression, including the upregulation of many transcription-factor genes. The transcription-factor genes listed in the light-blue shaded box were upregulated by all the stresses to some extent. The other transcription-factor genes listed are color coded and are examples of genes that are upregulated by individual stresses or by two of the stresses (dark blue, osmotic stress; green, anisomycin; purple, TNFα). Functional categories of genes that were enriched are depicted at the bottom of the figure.