Table 2.
K-means clustering of down-regulated genes (Set 4).
| Putative Id | Uniprot Accession | Score | Description | Fold change (6, 24, 72, 120 h) |
|---|---|---|---|---|
| Set 4 (54 genes): Delayed and persistent down-regulation | ||||
| Peroxisome proliferator-activated receptor-binding protein |
Q15648 |
7E-25 |
Transcription |
-1.08, -1.64, 1.03, -1.28 |
| RNA polymerase B transcription factor 3 | P20290 | 2E-71 | Transcription | -1.22, 1.18, 1.01, -2.17 |
| Thioredoxin-binding protein 2 | Q9H3 M7 | 3E-22 | Transcriptional repression | -1.17, -1.85, -1.21, -1.08 |
| Probable ATP-dependent RNA helicase DDX48 |
Q91VC3 |
1E-140 |
RNA splicing |
-1.16, 1.13, 1.15, -2.17 |
| Cleavage and polyadenylation specificity factor 5 |
Q7T3C6 |
1E-125 |
mRNA processing |
-1.21, 1.42, -1.05, -2.56 |
| 40S ribosomal protein S25 | Q6Q311 | 5E-30 | Translation | -1.14, 1.01, 1.13, -2.63 |
| Translation initiation factor eIF-2B subunit gamma |
Q4R6T3 |
8E-6 |
Translation |
-1.03, -3.85, -2.78, -1.51 |
| Phospholipase A2 | P00592 | 1E-31 | Signal transduction | 1.09, -1.24, -1.45, -3.03 |
| Phospholipase D | O17405 | 4E-27 | Signal transduction | 1.04, -1.37, -1.21, 1.24 |
|
Calcium/calmodulin-dependent protein kinase type II δ chain |
Q13557 |
2E-70 |
Signal transduction/regulation of cell growth |
-1.21, -1.77, -1.82, -1.24 |
|
Proto-oncogene tyrosine-protein kinase receptor ret |
P35546 |
1E-25 |
Signal transduction/development |
-1.10, -1.11, -1.21, -1.92 |
|
Translationally-controlled tumor protein |
Q9DGK4 |
2E-57 |
Apoptosis, negative regulator |
-1.43, 1.16, 1.08, -2.78 |
| Trypsin | P35034 | 2E-37 | Proteolysis/digestion | -1.12, -1.06, -1.15, -2.94 |
| Elastase-1 | Q7SIG3 | 1E-112 | Proteolysis/pancreas | -1.21, -1.49, -1.47, -2.17 |
| α-1-antitrypsin-like protein CM55-MS |
O54758 |
3E-69 |
Protease inhibitor/extracellular |
-1.13, -1.25, -1.52, -1.01 |
| Nucleolar GTP-binding protein 1 |
Q9BZE4 |
4E-41 |
Negative regulation of protein ubiquitination |
-1.01, 1.16, -1.05, -3.57 |
| Rotamase 1B | P68106 | 2E-52 | Protein folding/cytoplasm | 1.42, -2.63, -2.17, -1.27 |
| Signal sequence receptor subunit α |
P45433 |
1E-101 |
Protein folding/ER |
-1.27, 1.87, 1.01, -3.03 |
|
Adenylosuccinate synthetase isozyme 2 |
P46664 |
8E-16 |
Nucleotide biosynthesis |
-1.03, -1.64, -1.57, -1.64 |
| Nicotinamide riboside kinase 2 | Q9NPI5 | 1E-73 | Nucleotide biosynthesis | -1.30, 1.03, 1.03, -2.78 |
|
Liver-specific uridine phosphorylase |
Q8CGR7 |
1E-84 |
Nucleotide catabolism |
1.51, -1.09, -1.72, 2.22 |
|
Malonate-semialdehyde dehydrogenase [acylating] |
Q07536 |
1E-131 |
Valine & pyrimidine metabolism |
-1.09, -1.04, -1.45, 1.14 |
| Urate oxidase | P11645 | 1E-111 | Purine metabolism | -1.08, -1.47, -1.41, -1.60 |
| Aspartate aminotransferase | P00504 | 0 | Amino acid catabolism | 1.16, -1.29, -1.96, 1.18 |
| Glycine decarboxylase | P15505 | 2E-10 | Glycine catabolism | 1.24, -1.36, -1.89, 1.38 |
|
Neutral and basic amino acid transport protein rBAT |
Q07837 |
6E-85 |
Cystine reabsorption |
1.62, -1.14, -1.30, -1.22 |
|
Fructose-biphosphate aldolase, muscle type |
P53445 |
6E-26 |
Glycolysis |
-1.26, -1.34,-1.61, -2.63 |
|
Cytochrome c oxidase subunit IV isoform 2 |
P80971 |
4E-66 |
Mitochondrial respiration |
-1.27, -1.29, -1.69, -2.02 |
|
NADH-ubiquinone oxidoreductase subunit B14.5b |
Q9CQ54 |
7E-19 |
Mitochondrial respiration |
1.37, -2.22, -1.92, 1.74 |
| Hemopexin | P02790 | 2E-44 | Heme transport | -1.22, -1.40, -2.08, -1.65 |
|
Solute carrier organic anion transporter family member 1C1 |
Q9EPZ7 |
1E-23 |
Ion transport |
-1.02, -1.85, -1.39, -1.07 |
| Alcohol dehydrogenase 1 |
P26325 |
3E-92 |
Oxidoreductase activity/xenobiotic metabolism |
-1.07, -2.38, -2.63, -5.55 |
| 17-β-hydroxysteroid dehydrogenase 11 |
Q6AYS8 |
4E-49 |
Oxidoreductase activity/xenobiotic metabolism |
1.53, -2.63, -1.82, 2.07 |
| Cytochrome P450 1A1 |
O42457 |
0 |
Oxidoreductase activity/xenobiotic metabolism |
-1.72, -4.35, -2.00, -1.57 |
| Cytochrome P450 2J1 |
P52786 |
3E-69 |
Oxidoreductase activity/xenobiotic metabolism |
1.02, -1.54, -1.06, -1.28 |
| Cytochrome P450 2J2 |
P51589 |
7E-63 |
Oxidoreductase activity/xenobiotic metabolism |
1.01, -1.59, 1.02, -1.15 |
| Cytochrome P450 2J6 |
O54750 |
2E-87 |
Oxidoreductase activity/xenobiotic metabolism |
1.34, -1.82, -2.00, -2.50 |
| Glutathione S-transferase 3 |
P26697 |
2E-63 |
Oxidoreductase activity/xenobiotic metabolism |
-1.15, -1.79, -1.54, -1.89 |
| Monoamine oxidase |
P49253 |
4E-66 |
Oxidoreductase activity/xenobiotic metabolism |
1.28, -1.82, -1.75, -1.59 |
| Retinol-binding protein II, cellular |
P50120 |
1E-51 |
Oxidoreductase activity/xenobiotic metabolism |
-1.23, -3.33, -3.03, -1.10 |
| α-2-HS-glycoprotein | Q9N2D0 | 2E-33 | Acute immune response | -1.13, -1.59, -1.85, -2.17 |
| Ig heavy chain Mem5 | P84751 | 4E-38 | Antigen binding | -1.30, -1.07, 1.03, -2.38 |
|
B-F histocompatibility F10 antigen |
P15979 |
4E-41 |
Antigen processing |
-1.15, 1.05, -1.45, -1.52 |
|
H-2 class II histocompatibility antigen, A-K α chain |
P01910 |
7E-25 |
Antigen processing |
-1.28, -1.03, -1.30, -1.19 |
| Fucolectin-1 (lectin pathway) | Q9I931 | 3E-37 | Complement activation | 1.04, -1.32, -1.35, -1.89 |
| Histamine N-methyltransferase | P50135 | 3E-75 | Histamine metabolism | -1.08, -1.69, -1.53, -2.17 |
| Macrophage migration inhibitory factor | P80177 | 1E-40 | Inflammatory response | -1.37, -1.37, -1.02, -1.48 |
| Interferon regulatory factor 8 | Q90871 | 1E-15 | Interferon signalling | 1.01, -1.67, -2.94, 1.28 |
| Centaurin-α 2 | Q9NPF8 | 3E-28 | GTPase activator | -1.23, -1.37, -1.03, -2.22 |
| Collagen α1(I) chain | P02457 | 4E-68 | Collagen component | 1.43, -1.82, -1.72, -1.24 |
| Gastrulation-specific G12-like protein | Q9CQ20 | 4E-18 | Microtubule depolymerization, inhibition | -1.01, -1.79, -1.89, -1.08 |
| Plakophilin-3 | Q9QY23 | 8E-26 | Cell adhesion | -1.45, -1.67, -1.56, 1.01 |
| Radixin | P26043 | 1E-24 | Actin filament capping | 1.32, -3.23, -2.04, -1.83 |
| Transmembrane protein 59 | Q9QY73 | 8E-69 | Membrane-bound protein | -1.36, -1.41, -1.25, -2.08 |
Genes involved in similar pathways or processes are grouped and with the same font (italic/non-italic).