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. Author manuscript; available in PMC: 2011 Apr 16.
Published in final edited form as: Circ Res. 2010 Feb 25;106(7):1303–1311. doi: 10.1161/CIRCRESAHA.109.210294

Figure 4. Id3-/- ApoE-/- mice have significantly more atherosclerosis than Id3+/+ ApoE-/- mice in the descending aorta.

Figure 4

Beginning at eight weeks of age, Id3+/+ ApoE-/- and Id3-/- ApoE-/- mice were fed a chow or Western diet for 16 or 32 weeks. Aortas were perfused with paraformaldehyde, harvested, opened longitudinally and stained with Sudan IV. En face lesion area was quantitated using Image-Pro 5.0 software. A, Representative vessels from Id3+/+ ApoE-/- and Id3-/- ApoE-/- mice. Regions shown are of the descending aorta from the bifurcation of the iliac arteries to the bifurcation of the left subclavian (left to right). B, Quantitation of lesion area by en face analysis in Id3+/+ ApoE-/- and Id3-/- ApoE-/- mice after 16 weeks of chow diet, 32 weeks of chow diet or 32 weeks of Western diet. Each point represents one animal. *: p = 0.001. **: p = 0.005.