Table 5.

Weighted means (SE) or proportion (SE) of MRI variables by weighted tertiles of each MMP/TIMP variable, and p-value for test for any differences between tertiles, adjusted by age, race, gender, smoking, hypertension, CRP, diabetes, total cholesterol, and HDL cholesterol, and restricted to participants with Max Wall Thickness >1.5 and Lipid Core=1.

MRI Variables	CLDA Variables	1st Tertile	2nd Tertile	3rd Tertile	P-Value*
Mean Fibrous Cap Thickness (mm) (n=544)*	MMP-1	0.682 (0.028)	0.642 (0.031)	0.700 (0.028)	0.3684
	MMP-2	0.678 (0.029)	0.673 (0.033)	0.678 (0.026)	0.9918
	MMP-3	0.682 (0.032)	0.683 (0.033)	0.668 (0.026)	0.9254
	MMP-7	0.684 (0.034)	0.640 (0.026)	0.701 (0.026)	0.2287
	MMP-8	0.673 (0.026)	0.652 (0.037)	0.700 (0.024)	0.5126
	MMP-9	0.663 (0.034)	0.664 (0.028)	0.702 (0.028)	0.6090
	TIMP-1	0.626 (0.024)	0.669 (0.032)	0.718 (0.027)	0.0439
Maximum Calcium Area (mm2) (n=545)*	MMP-1	0.032 (0.003)	0.038 (0.004)	0.044 (0.006)	0.0642
	MMP-2	0.042 (0.009)	0.037 (0.003)	0.037 (0.004)	0.8757
	MMP-3	0.034 (0.003)	0.036 (0.004)	0.044 (0.006)	0.3264
	MMP-7	0.027 (0.002)	0.045 (0.008)	0.043 (0.004)	0.0002
	MMP-8	0.045 (0.008)	0.033 (0.003)	0.038 (0.004)	0.2209
	MMP-9	0.042 (0.006)	0.039 (0.004)	0.033 (0.003)	0.3015
	TIMP-1	0.035 (0.004)	0.042 (0.007)	0.038 (0.003)	0.4951
Maximum Lipid Core Area (mm2) (n=554)*	MMP-1	0.102 (0.011)	0.115 (0.010)	0.109 (0.010)	0.6936
	MMP-2	0.098 (0.007)	0.110 (0.009)	0.115 (0.013)	0.3876
	MMP-3	0.110 (0.009)	0.097 (0.008)	0.115 (0.011)	0.3724
	MMP-7	0.099 (0.008)	0.121 (0.013)	0.105 (0.011)	0.3207
	MMP-8	0.112 (0.012)	0.101 (0.009)	0.111 (0.011)	0.7276
	MMP-9	0.101 (0.010)	0.1348 (0.013)	0.0922 (0.007)	0.0062
	TIMP-1	0.089 (0.008)	0.1325 (0.014)	0.0990 (0.008)	0.0146

^*n=number of included participants