Table 1.

The catalytic rate constants for O₂·⁻ dismutation (k_cat in M⁻¹s⁻¹ at 25°C) and ONOO⁻ reduction (k_red in M⁻1 s⁻¹ at 37°C); lipophilicity expressed in terms of partition between n-octanol and water, P_OW for oxidized, Mn^IIIPs and reduced Mn^IIPs; thermodynamic property, metal-centered reduction potential for the redox couple Mn^IIIP/Mn^IIP, E_1/2 in mV vs NHE; and blood to brain ratio for ethyl, MnTE-2-PyP⁵⁺ and hexyl, MnTnHex-2-PyP⁵⁺ analogues.

MnP	log k_cat (O₂·⁻)	log k_red(ONOO⁻)	E_1/2	P_OW(Mn^IIIP)	P_OW(Mn^IIP)	R_f Blood : brain ratio
MnTE-2-PyP⁵⁺	7.76^a	7.53^b(>7)^c	+228^a	−6.89^d	−4.69^e	0.23	100^f
MnTnHex-2-PyP⁵⁺	7.48^a	7.11^b	+314^a	−2.76^d	−1.64^e	0.48	8^f

(Batinic-Haberle, 2002);

(Ferrer-Sueta et al., 2003);

value in parenthesis relates to Mn^II(Ferrer-Sueta et al., 2006);

(Kos et al., 2009);

Data calculated based on R_f values for metal-center reduced Mn(II) porphyrins (by ascorbate) on TLC silica plates in KNO₃ - saturated H₂O : H₂O : acetonitrile = 1:1:8 and P_OW vs R_f relationships, log P_OW= 12.18 × R_f −7.43, from ref (Kos et al., 2009); R_f, a thin-layer chromatographic retention factor is a ratio of MnP path over solvent path, P_OW partition coefficient between n-octanol and water;

Spasojevic et al, unpublished.