Table 1.
Patient Characteristics
| Characteristic | Total | SD | PD | PP | P |
|---|---|---|---|---|---|
| Total no. of patients | 27 | 13 | 8 | 6 | |
| Age, years | 1 : 0.761 | ||||
| Mean | 51.8 | 53.6 | 51.1 | 48.8 | 2 : 0.561 |
| SEM | 3.1 | 4.1 | 6.9 | 6.8 | 3 : 0.817 |
| Pathology | 1 : 0.075 | ||||
| Grade 3 | 4 | 3 | 0 | 1 | 2 : 0.746 |
| Grade 4 | 23 | 10 | 8 | 5 | 3 : 0.180 |
| KPS | 1 : 0.590 | ||||
| < 70 | 4 | 2 | 2 | 0 | 2 : 0.202 |
| 70+ | 23 | 11 | 6 | 6 | 3 : 0.115 |
| Location | 1 : 0.380 | ||||
| Frontal/temporal | 16 | 9 | 4 | 3 | 2 : 0.423 |
| Other | 11 | 4 | 4 | 3 | 3 : 0.990 |
| RPA | |||||
| 1 | 2 | 2 | 0 | 0 | 1 : 0.689 |
| 2 | 0 | 0 | 0 | 0 | 2 : 0.305 |
| 3 | 7 | 2 | 2 | 3 | 3 : 0.606 |
| 4 | 6 | 3 | 2 | 1 | |
| 5 | 9 | 4 | 3 | 2 | |
| 6 | 3 | 2 | 1 | 0 | |
| Initial tumor volume, cm3 | 1 : 0.338 | ||||
| Mean | 36.4 | 36 | 46.9 | 23.1 | 2 : 0.230 |
| SEM | 4.6 | 6.6 | 8 | 7.8 | 3 : 0.065 |
| Surgery | |||||
| Biopsy | 7 | 0 | 5 | 2 | 1 : 0.002† |
| Subtotal | 9 | 7 | 1 | 1 | 2 : 0.045† |
| Near GTR | 11 | 6 | 2 | 3 | 3 : 0.537 |
| Radiation therapy dose, Gy | 1 : 0.009* | ||||
| Mean | 71.8 | 69.5 | 76 | 70.5 | 2 : 0.820 |
| SEM | 1.5 | 2 | 1.5 | 3.9 | 3 : 0.188 |
NOTE. Numerical identifiers refer to individual comparisons (1: SD v PD, 2: SD v PP, and 3: PP v PD).
Abbreviations: SD, stable disease; PD, progressive disease; PP, pseudoprogression; KPS, Karnofsky performance score; RPA, Recursive Partitioning Analysis; GTR, gross total resection.
*
Two-sided unpaired student's t test.
†
Likelihood ratio test.