Table 4.

Newer therapies with demonstrated efficacy in Raynaud’s phenomenon

Agents	Class	Route	RP population	Effect
MQX-503	Nitrate	Topical	Primary and secondary	Reduced attack severity
Iloprost	Prostaglandin analog	Intravenous	Secondary	Reduced duration, frequency, and severity of attacks; improved ulcer healing
Bosentan	Endothelin receptor antagonist	Oral	Secondary	Reduced number of new digital ulcers
Sildenafil	Phosphodiesterase type 5 inhibitor	Oral	Secondary	Reduced duration, frequency, and severity of attacks; improved ulcer healing
Tadalafil	Phosphodiesterase type 5 inhibitor	Oral	Secondary	Reduced duration, frequency, and severity of attacks; improved ulcer healing