Table 1.
Serum DNA Signatures Predictive of RRMS and Disease Activity Obtained by MVR Analysis
| Normal* | c statistic | Stable | c statistic | |
|---|---|---|---|---|
| Genes† | ||||
| All MS | PARN(+), COMMD10(+), TMEM117(+), SPAG17(−), NEB(−), PTPRR(−), TRIO(−) | 0.97 (0.85–0.99) | ||
| Relapsing MS | GRID2(−), CHL1(+), PLCB1(−), DTNB(−), CNTNAP5(+), NELL2(−), FHOD3(−) | 0.98 (0.81–0.98) | SATB2(−), ELAVL2(−), CUGBP2(−) | 1.0 (0.90–1.0) |
| Stable MS | FRMD3(+), PLD5(+), GPR158(−), HPSE2(−), PPM1H(−), ABLIM1(−), RHBDD1(−) | 0.98 (0.90–1.0) | ||
| Repeats‡ | ||||
| All MS | (TG)n(+), AT_rich(−), L1MA4(−), L1M5(−), L1MD(−), (GGTTG)n(+), L1MC(−) | 0.98 (0.93–1.0) | ||
| Relapsing MS | AT_rich(−), L1M5(−), Hs17(+), L1MD(−), Satellite(−), HERVK-int(−), L1MA4(−) | 1.0 (0.98–1.0) | (CAA)n(−), LTR16B1(−), Satellite(−), MER21-int(+), (TCTCTG)n(−), L1ME4a(−) | 1.0 (0.90–1.0) |
| Stable MS | (TG)n(+), AT_rich(−), CER(+), L1MC(−), (TC)n(+), L1MD(−), LTR16A(+) | 1.0 (0.98–1.0) |
*
(+) signifies an excess compared with the normal database; (−) signifies a reduction compared with the normal database.
†
Derived from Supplemental Tables S1 to S4 (see http://jmd.amjpathol.org).
‡
Derived from Supplemental Tables S5 to S8 (see http://jmd.amjpathol.org).