Table 2.
Gene Functions of Dysregulated CNAs from Patients with RRMS Versus Healthy Control Subjects
| Relapsing MS versus normal | Stable MS versus normal | Relapsing MS versus normal | Relapsing MS versus stable MS | Total | |
|---|---|---|---|---|---|
| Cytoskeleton/cell morphology | NEBL, DTNB, KLHL1, FHOD3, ARHGAP15 | ABLIM1, FRMD3, FARP1, CLASP1 | SNTG2, SPAG17, NEB, SGCZ | NEBL, FHOD3, UBR4, FARP1, SORBS1 | 18 |
| Neuronal growth factors/growth regulators/differentiation regulators | NELL2, MDGA2, CHL1, CNTN5, CNTNAP5, NAV3, FAM19A2 | SDK1 | TRIO, PDGFD, PTPRR | CNTNAP5, CHL1, ELAVL2, NEGR1 | 15 |
| Phosphatases/phospholipases/kinases | DGKI, MAST4, ITPK1, PLCB1 | PPM1H, PLD5, KSR2 | ITPK1, PRKCB1, KSR2, PLD5 | 11 | |
| Nervous signal transduction | GRID2, GRIA1 | GRID2, SLC44A5 | GRID2, STXBP6 | 6 | |
| Ion channels/ion transporters/ion channel interacting | NKAIN3 | KCNMA1 | SFXN5 | PDZD2 | 4 |
| RNA processing | SRPK2, PARN | CUGBP2 | 3 | ||
| Polysaccharide metabolism | HPSE | CHSY2 | 2 | ||
| G protein-coupled receptors | GPR158 | GPR158 | 2 | ||
| Apoptosis | WWOX, ELMO1 | 2 | |||
| Cell cycle regulation | MCC | 1 | |||
| Proteases | RHBDD1 | 1 | |||
| Inflammation | COMMD10 | 1 | |||
| Lipid rafts | RFTN1 | 1 | |||
| Unclassified | MDS1 | PLEKHA5, SPATA5, TMEM117 | CUBN, SATB2, CCDC60, SERGEF, GSG1L, MDS1, MUC16, EBF1, TBC1D22A, SSBP2 | 14 | |
| Total | 20 | 15 | 18 | 28 | 81 |
Genes with exclusive or predominant expression in nervous tissues are in bold; genes included in MVR(C) are underlined.