Table 3.

Test Results of TCRG, TCRB, and Combined Use of TCRG and TCRB When Interpreting Oligoclonality as Either Negative or Positive

Classification of oligoclonal pattern	Clonality test(s) used	Test interpretation	Definitions of “positive” and “negative”	# of MF	# of ID	Sensitivity	Specificity
As negative	TCRG alone	Positive	Monoclonal	44	22	64%	84%
		Negative	Oligoclonal or polyclonal	25	111
	TCRB alone	Positive	Monoclonal	44	22	64%	84%
		Negative	Oligoclonal or polyclonal	25	111
	TCRG and TCRB	Positive	Both tests are monoclonal	34	9	49%	93%
		Negative	At least one test is not monoclonal	35	124
	TCRG and TCRB	Positive	At least one test is monoclonal	54	35	78%	74%
		Negative	Neither test is monoclonal	15	98
As positive	TCRG alone	Positive	Monoclonal or oligoclonal	51	22	74%	84%
		Negative	Polyclonal	18	111
	TCRB alone	Positive	Monoclonal or oligoclonal	51	23	74%	83%
		Negative	Polyclonal	18	110
	TCRG and TCRB	Positive	Both tests are monoclonal or oligoclonal	40	9	58%	93%
		Negative	At least one test is polyclonal	29	124
	TCRG and TCRB	Positive	At least one test is monoclonal or oligoclonal	62	36	90%	73%
		Negative	Both tests are polyclonal	7	97
	Total #			69	133