Table 5.

Recommended Pretest Probability Cut-Offs and Optimal TCRG and/or TCRB Testing Methods

Pretest MF probability	Recommended use of TCR clonality test(s)	Rationale
<0.15	Of limited utility	Increment of PPV would not be adequate to change patient management
		Little clinical significance
0.15 to 0.50	Combined use of TCRG and TCRB tests	Low pretest probability, specificity is more important
	Both tests need to be positive for the TCR test to be reported as supporting clonal process	Maximize PPV and minimize possibility of false positive results (1-PPV)
0.50 to 0.75	Combined use of TCRG and TCRB tests	Higher pretest probability, sensitivity is more important
	At least one test needs to be positive for the TCR test to be reported as supporting clonal process	Maximize NPV and minimize possibility of false negative results (1-NPV)
>0.75	Of limited utility	Change of MF probability would not change patient management
		Little clinical significance