Table 1.
Proteins significantly up/down regulated in LTM vs. controls
| Protein description | Accession number | PLGS Score | Mass kDa. | No. of MS/MS Spectra | Seq. Coverage % | Fold change LTM vs. Naive | p-value | Fold change LTM vs. Yoked | p-value |
|---|---|---|---|---|---|---|---|---|---|
| Kinesin like protein KIF14 | Q15058 | 109.68 | 186.49 | 21 | 13 | 1.12 | < 0.01 | 1.19 | < 0.01 |
| Canalicular multispecific organic anion transporter | O15438 | 74.4 | 169.34 | 24 | 23 | 1.11 | 0.01 | 1.18 | < 0.01 |
| UHRF1 binding protein | Q6BDS2 | 65.7 | 159.49 | 10 | 8 | 1.16 | < 0.01 | 1.25 | < 0.01 |
| Putative hexokinase HKDC1 | Q2TB90 | 53.72 | 102.52 | 2 | 2 | 1.19 | 0.01 | 1.39 | < 0.01 |
| Uncharacterized protein C2orf54 | Q08AI8 | 49.33 | 49.57 | 11 | 31 | 1.12 | 0.05 | 1.16 | 0.01 |
| Adenylate cyclase type 8 | P40145 | 87.68 | 140.12 | 35 | 36 | 1.22 | < 0.01 | 1.11 | 0.03 |
| Bile salt export pump | O95342 | 43.39 | 146.41 | 1 | 1 | 1.12 | 0.04 | 1.11 | 0.03 |
| Mitogen activated protein kinase kinase kinase 1 | Q13233 | 59.93 | 164.47 | 13 | 12 | 1.11 | 0.01 | 1.11 | 0.04 |
| 5 azacytidine induced protein 1 | Q9UPN4 | 91.48 | 122.06 | 18 | 17 | 0.93 | < 0.01 | 0.93 | < 0.01 |
| Zinc finger protein 28 homolog | Q8NHY6 | 79.58 | 98.71 | 13 | 14 | 0.93 | 0.03 | 0.8 | < 0.01 |
| Kelch repeat and BTB domain containing protein 5 | Q2TBA0 | 37.8 | 69.26 | 9 | 16 | 0.85 | 0.01 | 0.78 | < 0.01 |
| Diacylglycerol kinase kappa | Q5KSL6 | 36.22 | 141.83 | 14 | 15 | 0.88 | < 0.01 | 0.88 | < 0.01 |
| Phosphatidylinositol 4 phosphate 3 kinase C2 domain containing alpha polypeptide | O00443 | 90.69 | 190.68 | 24 | 17 | 0.92 | 0.04 | 0.88 | 0.01 |
| Acyl CoA dehydrogenase family member 10 | Q6JQN1 | 67.81 | 118.83 | 11 | 11 | 0.93 | 0.03 | 0.92 | 0.01 |
| Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Q9ULH1 | 60.8 | 125.47 | 15 | 15 | 0.88 | 0.03 | 0.88 | 0.01 |
| ATP binding cassette sub family A member 3 | Q99758 | 47.19 | 191.36 | 16 | 13 | 0.88 | 0.01 | 0.92 | 0.01 |
| Cytochrome P450 26A1 | O43174 | 41.39 | 56.2 | 6 | 14 | 0.87 | 0.03 | 0.89 | 0.02 |
| Tyrosine protein kinase JAK2 | O60674 | 56.35 | 130.67 | 10 | 9 | 0.92 | 0.03 | 0.9 | 0.03 |
| NTPase KAP family P loop domain containing protein 1 | Q17RQ9 | 52.69 | 67.78 | 13 | 26 | 0.83 | 0.01 | 0.88 | 0.03 |
| Ectonucleotide pyrophosphatase phosphodiesterase family member 2 | Q13822 | 47.65 | 99 | 9 | 14 | 0.83 | 0.05 | 0.83 | 0.03 |
| Multidrug resistance associated protein 9 | Q96J65 | 59.07 | 152.3 | 1 | 1 | 0.86 | 0.02 | 0.94 | 0.05 |
Accession number for Swiss Prot.
PLGS Score is calculated by the Protein Lynx Global Server (PLGS 2.2.5) software using a Monte Carlo algorithm to analyse all available mass spec. data and is a statistical measure of accuracy of assignation. A higher score implies greater confidence of protein identity [16].