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. 2010 Apr 27;5(4):e10357. doi: 10.1371/journal.pone.0010357

Table 2. Phenotype of spleen derived cells.

	Untreated Balb/c Mice N = 5	Islet-Tx N = 11	NPC-Tx N = 6	Co-NPC-Tx N = 10	P
CD4⁺	31±2	24±3	27±6	15±8 ^a ^, ^b ^, ^c	<0.001
- CD25⁺	5±1	18±7 ^a	10±6	26±8 ^a ^, ^c	<0.001
- FoxP3⁺	15+2	18±4	16±3	23±2 ^a ^, ^b ^, ^c	<0.001
- FoxP3⁺/CD25⁺	9+1	11±5	7±3	16±3 ^a ^, ^b ^, ^c	<0.001
- CD62L⁺	72±3	60±9	Nt	58±16	Ns
- CD25⁺/CD62L⁺	4±1	9±4 ^a	Nt	10±2 ^a	0.003
- CD45Rb high⁺	80±2	56±7 ^a	57±5 ^a	53±9 ^a	<0.001
CD8⁺	11±8	8±3 ^a	6±2 ^a	6±2 ^a	0.001
- CD45Rb high⁺	93±1	75±6^a	71±6^a	63±20^a	0.002
CD14⁺	1±0.2	4±3	1±1	4±3	Ns
Gr1⁺	1±0.2	3±4	5±7	3±2	Ns
Gr1^low/B220⁺	0.2±0.5	4±2 ^a ^, ^c	2±1	4±2 ^a ^, ^c	<0.001
CD19⁺/B220⁺	41±3	53±7	42±2	50±20	Ns
- I-Ab⁺	1.5±0.3	12±7 ^a	3±0.8	22±10 ^a ^, ^b ^, ^c	<0.001
- CD86⁺	0.5±0.5	21±14 ^a ^, ^c	7±3	37±7 ^a ^, ^b ^, ^c	<0.001
CD11b⁺	1.5±0.1	4.2±2.3	7.8±2.9	4.8±2.1 ^a ^, ^b ^, ^c	<0.001
- I-Ab⁺	1.14±0.6	67±37 ^a	33±25	89±8 ^a ^, ^c	<0.001
- CD80⁺	9±2	75±31 ^a	54±31 ^a	94±4 ^a ^, ^c	<0.001
- CD86⁺	9±2	73±32 ^a	46±30	89±14 ^a ^, ^c	<0.001

Data are expressed as percentage ±SD. Statistical analysis was performed by one-way ANOVA with Bonferroni post-hoc test:

^a

= p<0.05 vs Balb/c Mice;

^b

= p<0.05 vs Islet-Tx;

^c

= p<0.05 vs NPC-Tx; ^d = p<0.05 vs Co-NPC-Tx. Ns = not statistically significant; Nt = not tested.