Table 3.
Dosing guidelines for agents used to treat panic disorder
| CLASS/AGENT | STARTING DOSE (MG/D) | TYPICAL EFFECTIVE DOSE (MG/D)* |
|---|---|---|
| SSRIs | ||
| Sertraline | 12.2–25 | 150–300 |
| Escitalopram | 5 | 10–30 |
| Fluoxetine | 2–5 | 40–80 |
| Fluvoxamine | 25 | 150–300 |
| Paroxetine | 5–10 | 40–60 |
| SNRI | ||
| Venlafaxine | 18.75–37.5 | 150–300 |
| Benzodiazepines | ||
| Alprazolam | 0.5–1.0 | 2–10 |
| Clonazepam | 0.25–0.5 | 2–6 |
| Tricyclics | ||
| Clomipramine | 10 | >200 |
| Desipramine | 10 | >300 |
| Imipramine | 10 | >300 |
| MAOIs | ||
| Phenelzine | 15 | >90 |
| Tranylcypromine | 10 | >70 |
| Antiepileptics | ||
| Valproate | 250–500 | 1,000–2,000 |
| Gabapentin | 100–200 | 600–3,400 |
| Levitracitam | 250–500 | 1500–3000** |
| Tiagabine | unknown | unknown |
| Vigabatrin | unknown | unknown |
*
4–6 weeks should be allowed to assess effectiveness
**
Information on dosing is anecdotal