Fig. 5.
a ACh-induced relaxation of PE contraction in endothelium-intact mesenteric arteries of C and LP rats. ACh-induced relaxation of PE contraction in the absence or presence of L-NAME (b) or ODQ (c) in C rats and LP rats (all semilog plots). Mesenteric rings were incubated in the absence or presence of L-NAME (10–4 mol/l) or ODQ (10–5 mol/l) for 30 min. Submaximal PE contraction was elicited, ACh was added and then the percentage of relaxation to PE contraction was measured. Data points represent means ± SEM of measurements in 10–12 mesenteric arterial rings from 5–6 rats of each group. * p < 0.05 compared to the C group.