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Changes in Kinetochore Dynein During Mitosis. Dynein is initially recruited to kinetochores before MT attachment (A.) and remains at kinetochores during the process of mono-orientation and association with the spindle (B.) After bi-oriented MT attachments are achieved (C.), dynein undergoes poleward movement and labels K-fibers and spindle poles. By anaphase onset (D.), dynein is prominent on spindle fibers but undetectable at kinetochores.
