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Model 1: Multiple Populations of Dynein Coexist at Kinetochores. One possibility suggested by the literature is that multiple populations of dynein coexist, are recruited by distinct receptors and perform different functions. This would allow dynein to mediate diverse functions such as MT attachment, generation of tension and SAC silencing. Receptors for these dynein subsets include RZZ, LIS-1/nudE/EL/nudC/CL, dynactin and Spindly.
