Table 1. Association between SNP rs10494366 in NOS1AP and clinical traits. Data are mean±SEM.
| Parameters | GG (n=40) | GT (n=50) | TT (n=10) | P value | |
|---|---|---|---|---|---|
| Dosage (mg/d) | 2.33±0.22 | 2.45±0.17 | 2.30±0.54 | 0.627 | |
| Age (year) | 50.35±1.37 | 53.33±1.32 | 51.80±2.72 | 0.442 | |
| Sex (male/female) | 27/13 | 32/18 | 7/3 | 0.905 | |
| BMI (kg/m2) | Baseline | 24.51±0.41 | 25.90±0.42 | 26.12±0.63 | 0.024 |
| 24 weeks | 24.45±0.43 | 25.73±0.43 | 25.27±0.69 | 0.083 | |
| Δ value | −0.02±0.15 | −0.17±0.20 | −0.84±0.50 | 0.322 | |
| Waist–hip ratio | Baseline | 0.91±0.01 | 0.92±0.01 | 0.91±0.01 | 0.976 |
| 24 weeks | 0.91±0.01 | 0.91±0.01 | 0.90±0.01 | 0.637 | |
| Δ value | 0.01±0.01 | −0.01±0.01 | −0.01±0.02 | 0.555 | |
| Glycated hemoglobin (%) | Baseline | 8.38±0.23 | 8.38±0.21 | 7.73±0.34 | 0.390 |
| 24 weeks | 6.31±0.14 | 6.20±0.09 | 6.12±0.18 | 0.756 | |
| Δ value | −2.07±0.23 | −2.18±0.22 | −1.61±0.33 | 0.629 | |
| Fasting plasma glucose (mmol/L) | Baseline | 9.73±0.33 | 9.30±0.25 | 9.68±0.69 | 0.908 |
| 24 weeks | 6.79±0.18 | 6.52±0.15 | 6.16±0.38 | 0.122 | |
| Δ value | −2.93±0.32 | −2.89±0.27 | −3.52±0.90 | 0.654 | |
| 2-h plasma glucose (mmol/L) | Baseline | 14.04±0.46 | 13.11±0.45 | 14.30±0.91 | 0.311 |
| 24 weeks | 9.06±0.38 | 8.84±0.31 | 8.55±0.74 | 0.963 | |
| Δ value | −5.44±0.61 | −4.96±0.59 | −5.74±1.04 | 0.763 | |
| HOMA-IR | Baseline | 4.87±0.43 | 5.85±0.35 | 7.11±1.05 | 0.030 |
| 24 weeks | 5.62±0.44 | 5.47±0.34 | 4.64±0.56 | 0.401 | |
| Δ value | 0.75±0.43 | −0.37±0.37 | −2.48±1.09 | 0.011 | |
| HOMA-B | Baseline | 46.45±10.41 | 54.96±4.40 | 57.40±6.59 | 0.005 |
| 24 weeks | 128.79±13.09 | 142.76±13.26 | 146.37±20.66 | 0.425 | |
| Δ value | 82.34±15.18 | 87.00±12.55 | 88.97±23.90 | 0.997 | |
| Fasting insulin (pmol/L) | Baseline | 68.95±6.64 | 86.45±4.85 | 97.53±7.90 | 0.007 |
| 24 weeks | 111.15±8.18 | 115.35±6.66 | 100.46±7.37 | 0.565 | |
| Δ value | 42.21±7.61 | 28.90±5.95 | 2.93±7.12 | 0.019 | |
| Acute insulin secretion (pmol/L) | Baseline | 155.28±20.12 | 183.60±17.49 | 162.49±20.51 | 0.960 |
| 24 weeks | 154.73± 20.95 | 184.26±15.02 | 195.05±32.57 | 0.513 | |
| Δ value | −6.15±16.01 | 1.59±17.29 | 32.56±22.28 | 0.623 | |
| Acute insulin secretion (pmol/L)/plasma glucose (mmol/L) | Baseline | 18.81±2.54 | 22.86±2.41 | 19.40±2.81 | 0.306 |
| 24 weeks | 22.46±3.04 | 29.89±2.25 | 30.69±6.12 | 0.037 | |
| Δ value | 2.78±2.64 | 7.13±2.91 | 10.13±4.47 | 0.147 |
BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-B, homeostasis model assessment of beta cell function; Δ value, which equals the value at 24 weeks minus the value at baseline.