Table 2. Mixed effect model analysis of 24-week repaglinide treatment effect, genotypes effect and their interaction effect.

Parameters	Repaglinide treatment effect (P value)	Genotypes effect (P value)	Genotypes and treatment interaction effect (P value)
BMI(kg/m2)	0.039	0.064	0.198
Waist-hip ratio	0.907	0.804	0.527
Glycated hemoglobin (%)	<0.001	0.427	0.585
Fasting plasma glucose (mmol/L)	<0.001	0.631	0.573
2-h Plasma glucose (mmol/L)	<0.001	0.494	0.328
HOMA-IR	0.056	0.824	0.013
HOMA-B	<0.001	0.881	0.806
Fasting insulin (pmol/L)	<0.001	0.812	0.103
Acute insulin secretion(pmol/L)	0.270	0.875	0.395
Acute insulin secretion (pmol/L)/Plasma glucose (mmol/L)	0.769	0.032	0.738