TABLE 3. Docking equilibria in the absence and presence of AUCG or AUCI for the WT and A261H ribozymes (see Scheme 2).

Ribozyme	$K_{\text{dock}}^{\text{ES}}$		Bound nucleophile	$K_{\text{dock}}^{\text{ES}•\text{AUCX}}$
	(unitless)	Relative		(unitless)	Relative
WT	18	(1.0)	AUCG	47*	(1.0)
			AUCI	18*	2.6
A261H	14	1.3	AUCG	3	16
			AUCI	8*	5.9

^*= calculated from the thermodynamic framework of Scheme 2