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Competitive Binding Model. Snf1 and Glc7 compete for binding to the same surface of Reg1. When bound to Glc7, Reg1 directs the phosphatase to the Snf1 activation loop thereby promoting the inactivation of Snf1 kinase activity. When bound to Snf1, Reg1 protects the Snf1 activation loop from dephosphorylation thereby stabilizing the active state of the Snf1 kinase.
