Figure 5.

The effects of L1 cytoplasmic domain mutations on L1-mediated branching, primary neurites (branches extending from the soma), and nodes (branches arising from a neurite, not the soma). Primary neurites and nodes were quantified. The mean ± SEM values of the mutant-transfected neurons were always normalized by the mean values of neurons transfected with WT hL1 in the same experiment. Values shown are the average of the mean ± SEM percentage values from three experiments. ANOVA (Fisher's PLSD) was done using Statview 4.5. Statistical significance is shown. ^***p < 0.001 in all three experiments; ^**p < 0.05 in all three experiments.