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. 2010 May;135(5):449–459. doi: 10.1085/jgp.201010417

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© 2010 Liu et al.

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Figure 5. — Functional effects of disulfide cross-links. (A–E) Currents due to the indicated subunit combinations in response to step depolarizations from −40 to +140 mV, and then back to −80 mV. The recordings were made in outside-out macropatches with 10 µM Ca²⁺ inside the pipette. (F–J) Currents obtained with the same macropatches as above 4 min after the addition of 100 nM iberiotoxin to the perfusion solution. (K) Mean and SD (n = 4–5) of inhibition after 4-min exposure to 100 nM iberiotoxin. (L) Mean time constants for activation (τ_ACT) (n = 4–5) for the indicated subunit combinations. (M) Mean time constants for deactivation (τ_DEACT) (n = 4–5). (N and O) Normalized G-V curves with 10 µM Ca²⁺ inside the pipette for the indicated subunit combinations. Fits of a Boltzmann equation were to the means and SD (n = 4–10) of normalized conductances from separate patches.