Table 2.
Summary of LIM-HD expression in developing inner ear. Level of expression is determined by observation of signal of a particular LIM-HD throughout the developmental stages.
| Lhx3 | Lhx5 | Lhx6 | Lhx9 | Isl1 | Isl2 | Lmx1a | Lmx1b | ||
|---|---|---|---|---|---|---|---|---|---|
| E10.5 | |||||||||
| Ot | – | – | – | – | + | – | + | – | |
| OG | – | – | – | – | + | – | – | – | |
| E12.5 | |||||||||
| Ves | +H | + | – | + | + | + | +NSE | + | |
| Coch | – | + | – | – | + | – | – | – | |
| CVG | – | + | – | + | + | – | –_ | + | |
| E14.5 | |||||||||
| Ves | +H | +SE | +SE | + | + | + | +NSE | +SE | |
| GN | – | + | + | + | + | + | – | + | |
| E16.5 | |||||||||
| Ves | +H | +SE | +SE | +SE | +S | +H,S | +NSE | +SE | |
| Coch | +H | + | + | + | + | + | +NSE | + | |
| GN | – | + | + | + | + | + | – | + | |
| E18.5 | |||||||||
| Ves | +H | +SE | +SE | +SE | +S | +H,S | +NSE | +SE | |
| Coch | +H | + | + | + | +S,GER | + | +SP | + | |
| GN | – | + | + | + | + | + | –_ | + | |
| P6 | |||||||||
| SE | +H | + | + | + | +HeC,GER | +H,S | +NSE | + | |
| GN | – | + | + | + | + | + | – | + |
The expression levels are classified +: detected; -: no expression. Ot- otocyst; OG- otic ganglions; Ves- vestibule; Coch- cochlea; CVG- cochleovestibular ganglions; GN- ganglion neurons; SE- sensory epithelia (include both hair cells and supporting cells); H- expression in hair cells; S- expression in supporting cells; GER- the greater epithelial ridge; NSE- non-sensory epithelia; HeC- Hensen cells.