Table 2.

Demographics, Medical History, and Baseline Medication Usage in the Groups Who Used Histamine-2 Receptor Antagonists Continuously and Intermittently and Nonusers

Variable	Continuous Users (n = 38)*	Intermittent Users (n = 165)†	Nonusers (n = 1,355)	Test Statistic (Degrees of Freedom)‡	P-Value
Age, mean ± SD	77.7 ± 7.3	77.4 ± 6.0	77.7 ± 6.6	0.08 (2,1555)	.92
Female, %	73.7	78.8	64.7	<0.01	<.001§
Education, years, mean ± SD	9.5 ± 3.1	9.8 ± 3.1	10.0 ± 2.9	0.71 (2,1555)	.49
Baseline cognitive score, mean ± SD¶	30.8 ± 2.0	31.3 ± 1.5	31.2 ± 1.6	1.89 (2,1555)	.15
Regular alcohol use, %	47.4	40.0	39.9	<0.01	.65
Hypertension, %	71.1	72.1	64.6	<0.01	.13
Diabetes mellitus, %	39.5	30.3	24.8	<0.01	.046
Stroke, %	18.4	13.9	10.2	<0.01	.09
Depression, %	18.4	20.0	6.1	<0.01	<.001§,‖
Antihyperlipidemia use, %	0.0	3.0	1.8	0.06	.40
Antiplatelet use, %	0.0	1.2	0.6	0.17	.45
Aspirin use, %	10.5	10.3	7.7	0.01	.34
Benzodiazepine use, %	2.6	4.8	2.2	0.01	.10
Medications with definite central anticholinergic activities use, %	21.1	18.2	7.6	<0.01	.02§,‖

^*Use during all participating waves.

^†Use during at least one participating wave but not at all waves.

^‡F statistic for continuous values; table probability from Fisher exact test for categorical values.

^§From the Community Screening Instrument for Dementia.

^¶Intermittent and nonusers are significantly different (P<.05).

^‖Continuous and nonusers are significantly different (P<.05).

SD = standard deviation.