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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Steroids. 2010 Feb 13;75(7):467–476. doi: 10.1016/j.steroids.2010.02.004

Fig. 4.

Fig. 4

Epigenetic modifications of nuclear receptors impact steroid hormone signaling. The nuclear receptor subfamily NR3 and NR4 is known to be epigenetically regulated (shown by the arrow). Demethylation of promoter region of the nuclear receptor (NR) leads to normal production of protein that binds to steroid hormones and translocates to the nucleus to activate target promoter areas. Methylation of promoter regions of NRs leads to decrease expression, hormone-binding, and activation of target promoters.