Table 2.

Univariate and multivariate hazard ratios of risk of death based on Lung Allocation Score, diagnosis, and transplant center volume.

	Hazard Ratio (95% CI)
	Lung Allocation Score group
Model	1 (≤46)	2 (47–59)	3 (60–79)	4 (80–100)
All recipients
Unadjusted	1.00 [reference]	1.08 (0.91 – 1.30)	1.52 (1.21 – 1.90)	2.03 (1.61 – 2.55)
Age-adjusted	1.00 [reference]	1.08 (0.90 – 1.30)	1.52 (1.22 – 1.91)	2.01 (1.63 – 2.58)
Multivariate*	1.00 [reference]	1.05 (0.87 – 1.27)	1.50 (1.19 – 1.89)	2.05 (1.62 – 2.61)
Multivariate + donor†	1.00 [reference]	1.01 (0.82 – 1.24)	1.59 (1.24 – 2.03)	1.97 (1.52 – 2.56)
By selected diagnoses‡
IPF	1.00 [reference]	1.12 (0.86 – 1.48)	1.87 (1.35 – 2.59)	1.87 (1.32 – 2.63)
COPD	1.00 [reference]	1.06 (0.47 – 2.39)	1.84 (0.76 – 4.48)	12.19 (6.17 – 24.08)
Cystic fibrosis	1.00 [reference]	1.39 (0.80 – 2.41)	1.43 (0.72 – 2.84)	1.56 (0.57 – 4.28)
Graft failure, all cause	1.00 [reference]	0.90 (0.46 – 1.77)	1.07 (0.41 – 2.77)	1.83 (0.94 – 3.56)
By center volume (transplants since LAS)*
< 80	1.00 [reference]	1.11 (0.70 – 1.77)	1.17 (0.62 – 2.20)	2.36 (1.17 – 4.76)
80–159	1.00 [reference]	1.07 (0.81 – 1.41)	1.57 (1.12 – 2.21)	2.18 (1.55 – 3.09)
160–239	1.00 [reference]	0.74 (0.45 – 1.22)	1.43 (0.89 – 2.30)	1.63 (1.00 – 2.66)
≥ 240	1.00 [reference]	1.33 (0.86 – 2.06)	1.72 (0.96 – 3.09)	2.14 (1.19 – 3.87)

^*adjusted for age, diagnosis group, ventilator use, and transplant center volume.

^†Multivariate and donor age, graft ischemic time, and donor PaO₂/FiO₂ ratio

^‡adjusted for age and transplant center volume.

^*adjusted for age and diagnosis group

LAS groups defined as 1 (LAS ≤46), 2 (LAS 47–59), 3 (LAS 60–79), 4 (LAS >80). IPF: idiopathic pulmonary fibrosis; COPD: chronic obstructive pulmonary disease