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Regulation of p21 by various microRNAs (miRNAs). (A) Schematic diagram showing the genomic structure of five miRNA clusters. miR-106a and miR-17 clusters are a paralogue of miR-106b cluster. miR-19-92 cluster is related to miR-106a-92 cluster. P53 is also differentially regulated by miR-125 and miR-29 clusters. (B) Multiple sequence alignment of six miRNAs. All of these miRNAs share a core seed region, nt 2–8.
