Plasma extravasation measured using Evans Blue after eccentric contraction of the masseter muscle. Note that significant plasma extravasation (asterisk, p<0.05) is evoked in the masseter 24h following EC but not in the overlying skin. Naive n=26, 4h n=7, 1d n=13, 2d n=6, 4d n=12, Box plot shows median with edges of box denoting 25th and 75th percentile.